Article
Non-coding recurrent mutations in chronic lymphocytic leukaemia.
Nature - 22 Oct 2015
Puente Xose S, Beà Silvia, Valdés-Mas Rafael, Villamor Neus, Gutiérrez-Abril Jesús, Martín-Subero José I, Munar Marta, Rubio-Pérez Carlota, Jares Pedro, Aymerich Marta, Baumann Tycho, Beekman Renée, Belver Laura, Carrio Anna, Castellano Giancarlo, Clot Guillem, Colado Enrique, Colomer Dolors, Costa Dolors, Delgado Julio, Enjuanes Anna, Estivill Xavier, Ferrando Adolfo A, Gelpí Josep L, González Blanca, González Santiago, González Marcos, Gut Marta, Hernández-Rivas Jesús M, López-Guerra Mónica, Martín-García David, Navarro Alba, Nicolás Pilar, Orozco Modesto, Payer Ángel R, Pinyol Magda, Pisano David G, Puente Diana A, Queirós Ana C, Quesada Víctor, Romeo-Casabona Carlos M, Royo Cristina, Royo Romina, Rozman María, Russiñol Nuria, Salaverría Itziar, Stamatopoulos Kostas, Stunnenberg Hendrik G, Tamborero David, Terol María J, Valencia Alfonso, López-Bigas Nuria, Torrents David, Gut Ivo, López-Guillermo Armando, López-Otín Carlos, Campo Elías
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and...
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