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Article

Novel Mutation Hotspots within Non-Coding Regulatory Regions of the Chronic Lymphocytic Leukemia Genome.

Scientific reports - 12 Feb 2020

Mosquera Orgueira Adrián, Rodríguez Antelo Beatriz, Díaz Arias José Ángel, Díaz Varela Nicolás, Alonso Vence Natalia, González Pérez Marta Sonia, Bello López José Luis

Abstract excerpt

Mutations in non-coding DNA regions are increasingly recognized as cancer drivers. These mutations can modify gene expression in cis or by inducing high-order chormatin structure modifications with long-range effects. Previous analysis reported the detection of recurrent and functional non-coding DNA mutations in the chronic lymphocytic leukemia (CLL) genome, such as those in the 3' untranslated region of NOTCH1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 32051441
DOI: 10.1038/s41598-020-59243-5
PMCID: PMC7015923

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