Structural and Functional Differences between 3-Repeat and 4-Repeat Tau Isoforms

doi:10.1074/jbc.m007489200

Article

Structural and Functional Differences between 3-Repeat and 4-Repeat Tau Isoforms

1 Dec 2000

Abstract excerpt

Tau, MAP2, and MAP4 are members of a microtubule-associated protein (MAP) family that are each expressed as "3-repeat" and "4-repeat" isoforms. These isoforms arise from tightly controlled tissue-specific and/or developmentally regulated alternative splicing of a 31-amino acid long "inter-repeat:repeat module," raising the possibility that different MAP isoforms may possess some distinct functional capabilities....

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