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Article

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

Journal of neurochemistry - 1 Mar 2004

Wang Junning, Gao Qing-Sheng, Wang Yingzi, Lafyatis Robert, Stamm Stefan, Andreadis Athena

Abstract excerpt

Tau is a microtubule-associated protein whose transcript undergoes complex regulated splicing in the mammalian nervous system. In humans, exon 10 of the gene is an alternatively spliced cassette which is adult-specific and which codes for a microtubule binding domain. Mutations that affect splicing of exon 10 have been shown to cause inherited frontotemporal dementia (FTDP). In this study, we reconstituted...

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Identifiers

PMID: 15009664
DOI: 10.1046/j.1471-4159.2003.02232.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.PMID 15009664Read ↗

tau Exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5' and 3' splice sites.Semantic proximity Read ↗

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FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10Semantic proximity Read ↗

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