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Article

Reprogrammed Transcriptome in Rhesus-Bovine Interspecies Somatic Cell Nuclear Transfer Embryos

25 Jul 2011

Abstract excerpt

BACKGROUND: Global activation of the embryonic genome (EGA), one of the most critical steps in early mammalian embryo development, is recognized as the time when interspecies somatic cell nuclear transfer (iSCNT) embryos fail to thrive. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we analyzed the EGA-related transcriptome of rhesus-bovine iSCNT 8- to 16-cell embryos and dissected the reprogramming process in...

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PMID: 21799794
DOI: 10.1371/journal.pone.0022197

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