Article

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

2020-02-06

Abstract excerpt

Mechanical signals from the extracellular microenvironment have been implicated in tumor and metastatic progression. Here, we identified nucleoporin NUP210 as a metastasis susceptibility gene for human estrogen receptor positive (ER+) breast cancer and a cellular mechanosensor. Nup210 depletion suppresses lung metastasis in mouse models of breast cancer. Mechanistically, NUP210 interacts with LINC complex protei...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20afeaf4-397b-5ba5-86ad-29c9681edde0
DOI: 10.1101/2020.02.05.936518

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical responseDOI 10.1101/2020.02.05.936518Read

The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.Semantic proximity Read

Nucleoporin-93 overexpression overcomes multiple nucleocytoplsamic trafficking bottlenecks to permit robust metastasisSemantic proximity Read

Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier functionSemantic proximity Read

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.Semantic proximity Read

Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stressSemantic proximity Read

Homer3 Promotes Aggressive Phenotypes in Triple-Negative Breast Cancer Through Cell Cycle- and MYC-Associated Programs.Semantic proximity Read

Loss of <i>Sun2</i> ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosisSemantic proximity Read

The Dual Roles of Lamin A/C in Macrophage MechanotransductionSemantic proximity Read

Life at the crossroads: the nuclear LINC complex and vascular mechanotransductionSemantic proximity Read

Mis-regulation of the Nucleoporins 98 and 96 lead to defects in protein synthesis that promote hallmarks of tumorigenesisSemantic proximity Read

Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity.Semantic proximity Read

Mechanistic insights and potential therapeutic approaches for NUP98 -rearranged hematologic malignanciesSemantic proximity Read