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Article

Homer3 Promotes Aggressive Phenotypes in Triple-Negative Breast Cancer Through Cell Cycle- and MYC-Associated Programs.

International journal of molecular sciences - 4 Aug 2026

Tsai Kuei-Yen, Chang Yu-Jia, Lin Jang-Chun, Prince G M Shazzad Hossain, Batzorig Uyanga, Lee Ai-Wei, Hung Chin-Sheng

Abstract excerpt

Homer proteins (Homer1-3) are scaffold proteins that mediate protein-protein interactions in signal transduction; however, the role of Homer3 in breast cancer (BC), particularly triple-negative breast cancer (TNBC), remains poorly defined. Here, we investigated the clinical relevance and functional significance of Homer3 in BC and TNBC. Publicly available datasets from TCGA and GEO were analyzed to evaluate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42589661
DOI: 10.3390/ijms27157009
PMCID: PMC13467463

Genes

MYC

Provenance

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