Host-cell Interactions of Engineered T cell Micropharmacies

Abstract excerpt

Genetically engineered, cytotoxic, adoptive T cells localize to antigen positive cancer cells inside patients, but tumor heterogeneity and multiple immune escape mechanisms have prevented the eradication of most solid tumor types. More effective, multifunctional engineered T cells are in development to overcome the barriers to the treatment of solid tumors, but the interactions of these highly modified cells with...

Topics

Open a Topic to create a Post that cites this publication.

• Antigens, Neoplasm
• Autoantigens
• CAR-T cell therapy research
• Clinical Trials as Topic
• Immunotherapy, Adoptive
• Protein Engineering
• Receptors, Antigen, T-Cell
• T-Lymphocytes, Cytotoxic

Identifiers and source

Literature Corpus work

20a9c8db-1c39-5175-8f54-94150f523285

DOI

10.1101/2023.04.05.535717