Article

Imperatorin derivative OW1, a new vasoactive compound, attenuates cell proliferation and migration by inhibiting Nox1-mediated oxidative stress

2022-04-25

Abstract excerpt

<h4>Background: </h4> Vascular remodeling is the common pathological basis of cardiovascular and cerebrovascular diseases. In previous studies, we identified a new imperatorin derivative, OW1, that had significant effects on vasodilation and inhibited vascular remodeling. OW1 reduced blood pressure and microvascular remodeling in thoracic aorta, heart, and kidney, and inhibited peroxide levels in serum from hypert...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20a0681d-c3fd-5ce6-a0c5-f78f2f278123
DOI: 10.21203/rs.3.rs-1583929/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Imperatorin derivative OW1, a new vasoactive compound, attenuates cell proliferation and migration by inhibiting Nox1-mediated oxidative stressDOI 10.21203/rs.3.rs-1583929/v1Read

Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.Semantic proximity Read

Pro-angiogenic activity of isofuran in rat brain endothelial cellsSemantic proximity Read

Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice.Semantic proximity Read

S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathwaySemantic proximity Read

NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype.Semantic proximity Read

Mechanistic analysis of compounds that modulate VEGF-A splicing in podocytes with therapeutic potential for diabetic nephropathySemantic proximity Read

Suppression of NADPH oxidase attenuates hypoxia-induced dysfunctions of endothelial progenitor cells.Semantic proximity Read

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validationSemantic proximity Read

<i>Panax notoginseng saponins</i> protect the blood–brain barrier against oxidative stress by activating the Akap12–PI3K/AKT–AQP1 signaling axisSemantic proximity Read

Phoenixin 20 Prevents ox-LDL-Induced Attachment of Monocytes to Human Aortic Endothelial cells (HAECs): A Protective Implication in AtherosclerosisSemantic proximity Read

Brown Adipose Tissue Regulates Small Artery Function Through NADPH Oxidase 4-Derived Hydrogen Peroxide and Redox-Sensitive Protein Kinase G-1α.Semantic proximity Read

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposureSemantic proximity Read