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<i>Panax notoginseng saponins</i> protect the blood–brain barrier against oxidative stress by activating the Akap12–PI3K/AKT–AQP1 signaling axis

2025-11-14

Abstract excerpt

Oxidative stress is a key pathological factor that contributes to blood–brain barrier (BBB) disruption during ischemic injury. Panax notoginseng saponins (PNS), the primary bioactive components of Panax notoginseng, possess potent antioxidative and vasoprotective activities. This study aimed to elucidate the molecular mechanisms by which PNS regulate endothelial integrity and BBB permeability under oxidative stres...

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Literature Corpus work
44c077b5-d577-5e04-bc38-64f3b1420f0a
DOI
10.1101/2025.11.14.688373
Open publication

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<i>Panax notoginseng saponins</i> protect the blood–brain barrier against oxidative stress by activating the Akap12–PI3K/AKT–AQP1 signaling axisDOI 10.1101/2025.11.14.688373
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