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Mechanistic analysis of compounds that modulate VEGF-A splicing in podocytes with therapeutic potential for diabetic nephropathy

2025-12-01

Abstract excerpt

Vascular endothelial growth factor A (VEGF-A) has an alternatively spliced variant, VEGF-A165b, formed when a distal 3’ splice site in exon 8 is selected. The anti-angiogenic and anti-permeability VEGF-A165b has reno-protective properties and has been shown to rescue kidney function in diabetic nephropathy (DN) mouse models (PMID 25542969). We previously identified three new compounds that can increase the express...

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Identifiers and source

Literature Corpus work
77a5658f-0e40-5c44-8f2d-abefc1e61518
DOI
10.1101/2025.11.27.690981
Open publication

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Mechanistic analysis of compounds that modulate VEGF-A splicing in podocytes with therapeutic potential for diabetic nephropathyDOI 10.1101/2025.11.27.690981
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