Article

Pax Protein Depletion in Proximal Tubules Triggers Conserved Mechanisms of Resistance to Acute Ischemic Kidney Injury and Prevents Transition to Chronic Kidney Disease

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Acute kidney injury (AKI) is a common condition that lacks effective treatments. In part this shortcoming is due to an incomplete understanding of the genetic mechanisms that control pathogenesis and recovery. Pax2 and Pax8 are homologous transcription factors with overlapping functions that are critical for kidney development and are re-activated in AKI. In this report, we examined the role of...

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Literature Corpus work: 208ff0c5-86c6-5100-b30b-4f0c06552fc1
DOI: 10.1101/2023.10.03.559511

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