Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.

American journal of physiology. Renal physiology - 1 Jan 2025

McElliott Madison C, Telang Asha C, Ference-Salo Jenna T, Al-Suraimi Anas, Chowdhury Mahboob, Otto Edgar A, Soofi Abdul, Dressler Gregory R, Beamish Jeffrey A

Abstract excerpt

Acute kidney injury (AKI) is a common clinical syndrome with few effective treatments. Though the kidney can regenerate after injury, the molecular mechanisms regulating this process remain poorly understood. Pax2 and Pax8 are DNA-binding transcription factors that are upregulated after kidney injury. However, their function during the response to AKI remains incompletely defined. In this report, we develop a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ischemia

Share to Kidney Tubules, Proximal

Share to PAX2 Transcription Factor

Share to PAX8 Transcription Factor

Share to Regeneration

Share to Reperfusion Injury

Source

Open in PubMed Open full text

Identifiers

PMID: 39620904
DOI: 10.1152/ajprenal.00289.2024
PMCID: PMC11918291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.PMID 39620904Read ↗

Pax Protein Depletion in Proximal Tubules Triggers Conserved Mechanisms of Resistance to Acute Ischemic Kidney Injury and Prevents Transition to Chronic Kidney DiseaseSemantic proximity Read ↗

Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney diseaseSemantic proximity Read ↗

What PAX genes do in the kidney.Semantic proximity Read ↗

Signaling pathways of PAX2 and its role in renal interstitial fibrosis and glomerulosclerosis.Semantic proximity Read ↗

Mice with a Pax2 missense variant display impaired glomerular repair.Semantic proximity Read ↗

Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse StudiesSemantic proximity Read ↗

Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney diseaseSemantic proximity Read ↗

FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons.Semantic proximity Read ↗

Pax genes in renal development, disease and regenerationSemantic proximity Read ↗

Mechanisms of epithelial repair and regeneration after acute kidney injury.Semantic proximity Read ↗

Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injurySemantic proximity Read ↗

Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney InjurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.