Article

Vitamin B12 Protects the Exacerbated Ischemia-Reperfusion Injury Induced Chronic-Kidney-Disease in Mice with Genetically Increased Elmo1

2025-09-18

Abstract excerpt

Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI) and a major driver of progression to chronic kidney disease (CKD). Oxidative stress is recognized as a central mediator of this transition. Engulfment and Cell Motility 1 (ELMO1) regulates cytoskeletal remodeling and reactive oxygen species generation through Rac1 activation, but its contribution to CKD progression remains poorly def...

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Literature Corpus work: 59c33194-2b29-5ad0-b4c7-b564f4e92d88
DOI: 10.20944/preprints202509.1454.v1

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