Article

Ultra-low DNA input into whole genome methylation assays and detection of oncogenic methylation & copy number variants in circulating tumour DNA

2020-02-12

Abstract excerpt

<h4>Background</h4> CpG methylation in cancer is ubiquitous and generally detected in tumour specimens using a variety of techniques at a resolution encompassing single CpG loci to genome wide. Analysis of samples with very low DNA inputs, such as formalin fixed (FFPE) biopsy specimens from clinical trials or circulating tumour DNA has been challenging and has only been typically at single CpG sites. Analysis of...

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Literature Corpus work: 20899d7c-3a49-5983-8a34-482b4e5f3b7e
DOI: 10.1101/2020.02.11.20021964

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