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Mechanisms of Methicillin Resistance in <i>Staphylococcus aureus</i>

2 Jun 2015

Abstract excerpt

Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PBP2a), with significantly lower affinity for β-lactams. This resistance allows cell-wall biosynthesis,...

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PMID: 26034890
DOI: 10.1146/annurev-biochem-060614-034516

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