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A high-throughput cytotoxicity screening platform reveals <i>agr</i> -independent mutations in bacteraemia-associated <i>Staphylococcus aureus</i> that promote intracellular persistence

2022-12-13

Abstract excerpt

Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus can persist and replicate within host cells, evading immune responses and causing host cell death. Classical methods for assessing S. aureus cytotoxicity are limited by testing culture supernatants and endpoint measurements that do not capture the phenotypic diversity of intracellular...

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Literature Corpus work
24f75ad9-9d99-5bb4-9d28-7ce8f3ce9fa3
DOI
10.1101/2022.12.11.519971
Open publication

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A high-throughput cytotoxicity screening platform reveals <i>agr</i> -independent mutations in bacteraemia-associated <i>Staphylococcus aureus</i> that promote intracellular persistenceDOI 10.1101/2022.12.11.519971
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