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Interference with lipoprotein maturation sensitizes methicillin-resistant <i>Staphylococcus aureus</i> to human group IIA secreted phospholipase A <sub>2</sub> and daptomycin

2022-02-06

Abstract excerpt

Methicillin-resistant Staphylococcus aureus (MRSA) has been classified as a high priority pathogen by the World Health Organization underlining the high demand for new therapeutics to treat infections. Human group IIA secreted phospholipase A 2 (hGIIA) is among the most potent bactericidal proteins against Gram-positive bacteria, including S. aureus . To determine hGIIA-resistance mechanisms of MRSA we screened...

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Literature Corpus work
c9441377-4598-56eb-ab1a-e27f9b166468
DOI
10.1101/2022.02.06.476181
Open publication

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