Back to search

Article

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer

2024-03-13

Abstract excerpt

<h4>ABSTRACT</h4> A subgroup of castration-resistant prostate cancer (CRPC) aberrantly expresses a gastrointestinal (GI) transcriptome governed by two GI-lineage-restricted transcription factors, HNF1A and HNF4G. In this study, we found that expression of GI transcriptome in CRPC correlates with adverse clinical outcomes to androgen receptor signaling inhibitor treatment and shorter overall survival. Bromo- and e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
363b7423-e7f0-5a45-aa0e-3a6bdff0daad
DOI
10.1101/2024.03.09.584256
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancerDOI 10.1101/2024.03.09.584256
Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)Semantic proximity
A prostate cancer gastrointestinal transcriptional phenotype may be associated with diminished response to AR-targeted therapySemantic proximity
Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived XenograftsSemantic proximity
BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockadeSemantic proximity
Resistance to BET Inhibitor Leads to Alternative Therapeutic Vulnerabilities in Castration-Resistant Prostate CancerSemantic proximity
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancerSemantic proximity
Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate CancerSemantic proximity
BET inhibitors in metastatic prostate cancer: therapeutic implications and rational drug combinationsSemantic proximity
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancerSemantic proximity
The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate CancerSemantic proximity
The Silver Lining in BET Protein Targeting for Advanced Prostate Cancer Pharmacotherapy: Recent UpdatesSemantic proximity
Super-Enhancer Network in Metastatic Prostate Cancer: A Bioinformatics and Experimental ApproachSemantic proximity
Select a neighboring publication to make it the new centre.