Article

Exploration of bioactive variants of the BMP7-derived p[63-82] peptide for ameliorating the OA-associated chondrocyte phenotype

2025-05-14

Abstract excerpt

<title>Abstract</title> <p><bold>Introduction:</bold>Osteoarthritis (OA) is a highly prevalent, age-associated joint disease characterized by cartilage degeneration, joint dysfunction, and chronic pain. We previously developed a bone morphogenetic protein 7 (BMP7) derived peptide p[63-82], which may be a novel disease-modifying treatment option for OA. In this study we aimed to optimize the bioactivity and biosta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 201d080d-be50-5f7e-91b8-f2368fe5374a
DOI: 10.21203/rs.3.rs-6411244/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploration of bioactive variants of the BMP7-derived p[63-82] peptide for ameliorating the OA-associated chondrocyte phenotypeDOI 10.21203/rs.3.rs-6411244/v1Read

Exploration of bioactive variants of the BMP7-derived p[63-82] peptide for ameliorating the OA-associated chondrocyte phenotype.Semantic proximity Read

Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic StrategiesSemantic proximity Read

Recent advances in the treatment of osteoarthritisSemantic proximity Read

[Peptides prevent the forming of secretory phenotype of chondrocytes associated with the aging.]Semantic proximity Read

Bioactive and Its Chondroprotective Effects in Ameliorating Osteoarthritis: A Focus on Nanoparticle TherapySemantic proximity Read

[Chondrocytes secretory phenotype associated with aging: role in the pathogenesis of osteoarthritis and prospects for peptide bioregulation.]Semantic proximity Read

Bioactive and Its Chondroprotective Roles in Ameliorating Osteoarthritis: A Focus on Nanoparticle TherapySemantic proximity Read

Multi-Target Gene Therapy for Osteoarthritis: Dual-Axis Modeling and In Silico ValidationSemantic proximity Read

P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axisSemantic proximity Read

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date.Semantic proximity Read

Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic OsteoarthritisSemantic proximity Read

Expression and characterization of a human BMP-7 variant with improved biochemical properties.Semantic proximity Read