Article
[Chondrocytes secretory phenotype associated with aging: role in the pathogenesis of osteoarthritis and prospects for peptide bioregulation.]
Advances in gerontology = Uspekhi gerontologii - 1 Jan 2023
Myakisheva S N, Linkova N S, Kozhevnikova E O, Ryzhak G A
Abstract excerpt
Osteoarthritis (OA) is a socially significant age-associated disease, for the treatment of which a search for new effective drugs is underway. The development of OA correlates with the development of the aging-associated secretory chondrocyte phenotype (SASP). The purpose of the review is to analyze the pool of signaling molecules that form SASP of chondrocytes in OA and substantiate the possibility of peptide...
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