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Article

Exploration of bioactive variants of the BMP7-derived p[63-82] peptide for ameliorating the OA-associated chondrocyte phenotype.

Arthritis research & therapy - 30 Jul 2025

Steijns Jessica S J, Welting Tim J M, Cremers Andy, Akker Guus G H van den, Emans Pieter J, Rhijn Lodewijk W van, Caron Marjolein M J

Abstract excerpt

INTRODUCTION: Osteoarthritis is a highly prevalent, age-associated joint disease characterized by cartilage degeneration, joint dysfunction, and chronic pain. We previously developed a bone morphogenetic protein 7 derived peptide p[63-82], which may be a novel disease-modifying treatment option for OA. In this study we aimed to optimize the bioactivity and biostability of this peptide in the intra-articular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40739530
DOI: 10.1186/s13075-025-03599-4
PMCID: PMC12312574

Genes

C2
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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