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Article

Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy

24 Jun 2025

Abstract excerpt

RATIONALE: Epilepsy presents significant sex-based disparities in prevalence and manifestation. Epidemiological studies reveal that epilepsy is more prevalent in males, with lesional types being more common, whereas idiopathic generalized epilepsies are more frequently observed in females. These differences stress the importance of considering sex-specific factors in epilepsy diagnosis, treatment, and mechanistic...

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PMID: 40571052
DOI: 10.1016/j.expneurol.2025.115361

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