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Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models of autism spectrum disorders

2022-04-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> PTEN Hamartoma Tumor Syndrome (PHTS) is characterized by frequent mutation in <italic>PTEN</italic> gene. PHTS patients have numerous neurological defects including macrocephaly and autism spectrum disorder. While clinical features of PHTS are likely the result of <italic>PTEN</italic> haploinsufficiency, the role of <italic>PTEN</italic> gene dosage in driving...

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Literature Corpus work
764be649-d075-507f-8a81-ecb3c1f11154
DOI
10.21203/rs.3.rs-1575672/v1
Open publication

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Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models of autism spectrum disordersDOI 10.21203/rs.3.rs-1575672/v1
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