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Article

Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.

Nature communications - 9 Aug 2024

Gao Yudong, Shonai Daichi, Trn Matthew, Zhao Jieqing, Soderblom Erik J, Garcia-Moreno S Alexandra, Gersbach Charles A, Wetsel William C, Dawson Geraldine, Velmeshev Dmitry, Jiang Yong-Hui, Sloofman Laura G, Buxbaum Joseph D, Soderling Scott H

Abstract excerpt

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism risk genes within the mouse brain for proximity-based endogenous proteomics, achieving the identification of high-specificity spatial proteomes. The resulting...

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Identifiers

PMID: 39122707
DOI: 10.1038/s41467-024-51037-x
PMCID: PMC11316102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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