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Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli

7 Jan 2021

Abstract excerpt

The antibiotic colistin (polymyxin E) is an amphipathic, non-ribosomally synthesized, cyclic lipopeptide, which is selectively bactericidal for gram-negative aerobic bacilli, as it targets lipopolysaccharide (LPS) molecules in their outer membranes [1].Colistin first acts by replacing Ca 2+ and Mg 2+ cations that stabilize the outer membrane through electrostatic interactions with the anionic phosphate groups of...

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PMID: 33411745
DOI: 10.1371/journal.pgen.1009262

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