Article
Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
mSphere - 11 Mar 2020
Janssen Axel B, Bartholomew Toby L, Marciszewska Natalia P, Bonten Marc J M, Willems Rob J L, Bengoechea Jose A, van Schaik Willem
Abstract excerpt
Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabilization and cell death. Here, we aimed to uncover the mechanisms of colistin resistance in nine colistin-resistant...
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