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Glycosite Mapping and <i>in situ</i> Mass Spectrometry Imaging of MUC2 Glycopeptides via On-slide Digestion with Mucinase StcE

2024-09-20

Abstract excerpt

Many cancers are characterized by altered mucin expression and glycosylation, although the mechanistic relationship between tumor glycosylation and disease progression is not well-defined. Herein, our goal was to map specific mucin glycoforms in diseased tissue, enabling correlation of the tumor glycan profile with malignant features. To this end, we developed a workflow implementing on-tissue digestion with mucin...

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Identifiers and source

Literature Corpus work
1fd84b4c-7fea-5ac7-b58a-d7ea033dc4f4
DOI
10.1101/2024.09.16.613285
Open publication

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Glycosite Mapping and <i>in situ</i> Mass Spectrometry Imaging of MUC2 Glycopeptides via On-slide Digestion with Mucinase StcEDOI 10.1101/2024.09.16.613285
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