Article

Native PGC-LC-MS Profiling Reveals Distinct O-Acetylation Patterns of Sialylated N-Glycans Across Mammalian Sera

2025-10-19

Abstract excerpt

O -acetylation of sialic acids represents an additional layer of structural diversity and biological complexity, occurring at various hydroxyl positions (commonly C-7, C-8, or C-9) of the sialic acid residue. This modification modulates the recognition of sialylated glycans by lectins, antibodies, and viral proteins, and contributes to viral tropism and host susceptibility, particularly in influenza and coronaviru...

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Literature Corpus work: 623823ac-52aa-5976-8e74-e55f0cecc681
DOI: 10.1101/2025.10.19.683285

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