Article

TNIK maintains a MYC-driven partial EMT state that supports proliferation and evasion of senescence in lung squamous cell carcinoma.

2026-08-31

Abstract excerpt

Lung squamous cell carcinoma (LUSC) is an aggressive malignancy characterized by high cellular plasticity and few targeted treatment options. TNIK overexpression is common in LUSC and promotes tumor growth, with TNIK inhibition sensitizing LUSC to radiotherapy, though the underlying mechanisms are not well defined. Through transcriptomic analyses and functional assays, we identified TNIK as a regulator of a MYC-de...

Identifiers and source

Literature Corpus work: 1fd22c83-46ed-56d3-a140-70df2e15281b
DOI: 10.64898/2026.08.28.747625

Open publication

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TNIK maintains a MYC-driven partial EMT state that supports proliferation and evasion of senescence in lung squamous cell carcinoma.DOI 10.64898/2026.08.28.747625Read

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