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Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1 , SMARCA4 , and PTEN mutations

1 Aug 2025

Abstract excerpt

The tumor microenvironment (TME) plays a crucial role in shaping the response to immunotherapy in non-small cell lung cancer (NSCLC). While immune checkpoint inhibitors (ICIs) have revolutionized NSCLC treatment, a significant proportion of patients exhibit primary or acquired resistance. Emerging evidence highlights the role of specific genetic alterations, Kelch-like ECH-associated protein 1 ( KEAP1 ), SWI /...

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PMID: 40764107
DOI: 10.1136/jitc-2025-012288

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