Article

AMPKα2 isoform mediates mTORC2 activation by glucose starvation in endothelial cells

2025-12-12

Abstract excerpt

AMP-activated protein kinase (AMPK) and the mechanistic target of rapamycin (mTOR) are central regulators of cellular metabolism. While AMPK is known to inhibit mTOR complex 1 (mTORC1), its role in regulating mTORC2 remains enigmatic, with recent evidence suggesting context-dependent activation. Here, we investigated the specific roles of AMPKα catalytic isoforms in coordinating mTOR signaling and functional metab...

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Literature Corpus work: 1f9b7981-3728-561f-b2a6-615a04cdfcac
DOI: 10.64898/2025.12.10.693448

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