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CompAIRR: ultra-fast comparison of adaptive immune receptor repertoires by exact and approximate sequence matching

19 Jul 2022

Abstract excerpt

MOTIVATION: Adaptive immune receptor (AIR) repertoires (AIRRs) record past immune encounters with exquisite specificity. Therefore, identifying identical or similar AIR sequences across individuals is a key step in AIRR analysis for revealing convergent immune response patterns that may be exploited for diagnostics and therapy. Existing methods for quantifying AIRR overlap scale poorly with increasing dataset...

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PMID: 35852318
DOI: 10.1093/bioinformatics/btac505

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