Article

Novel engineered chimeric engulfment receptors trigger T-cell effector functions against SIV infected CD4+ T cells

2022-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV) infected cells express phosphatidylserine (PS) early post-infection. We tested whether chimeric engulfment receptor (CER) T cells designed to recognize PS-expressing cells could eliminate SIV infected cells. Lentiviral CER co...

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Literature Corpus work: 1f6c4bf0-0bee-5361-9e4a-2d2f087263e2
DOI: 10.1101/2022.06.21.495546

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