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Article

TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis

26 Jun 2019

Abstract excerpt

BACKGROUND: T cell immunoglobulin mucin domain-1 (TIM-1) is a phosphatidylserine (PS) receptor, mediating filovirus entry into cells through interactions with PS on virions. TIM-1 expression has been implicated in Ebola virus (EBOV) pathogenesis; however, it remains unclear whether this is due to TIM-1 serving as a filovirus receptor in vivo or, as others have suggested, TIM-1 induces a cytokine storm elicited by...

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PMID: 31242184
DOI: 10.1371/journal.pntd.0006983

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