Article

Microsecond molecular dynamics of SOD1 variants suggest a structural basis for divergent ALS clinical outcomes

2026-09-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by progressive motor neuron degeneration. Mutations in the SOD1 gene represent the second most common genetic cause of ALS (ALS), and distinct SOD1 missense variants present with markedly different clinical profiles. A4V leads to an aggressive form of the disease (median survival ∼1y), H46R confers a mild, slowly progressive cou...

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Literature Corpus work: d416d7b3-876e-51ec-910e-ab3ad0fbf992
DOI: 10.64898/2026.08.29.747999

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