Article

Accelerated Missense Mutation Identification in Intrinsically Disordered Proteins using Deep Learning

2024-07-10

Abstract excerpt

<h4>ABSTRACT</h4> We use a combination of Brownian dynamics (BD) simulation results and Deep Learning (DL) strategies for rapid identification of large structural changes caused by missense mutations in intrinsically disordered proteins (IDPs). We used ∼ 6500 IDP sequences from MobiDB database of length 20 − 300 to obtain gyration radii from BD simulation on a coarse-grained single bead amino acid model (HPS2 mod...

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Literature Corpus work: aba82fe9-f0bb-564b-a57c-375301ddc30d
DOI: 10.1101/2024.07.07.602404

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