Article

Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants

2021-09-25

Abstract excerpt

Many pathogenic missense mutations are found in protein positions that are neither well-conserved nor belong to any known functional domains. Consequently, we lack any mechanistic underpinning of dysfunction caused by such mutations. We explored the disruption of allosteric dynamic coupling between these positions and the known functional sites as a possible mechanism for such mutations. In this study, we present...

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Identifiers and source

Literature Corpus work: faf52555-97a3-57c3-a860-69fbd27a05b7
DOI: 10.1101/2021.09.24.461738

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