Article

Therapeutic targeting of tumour metabolism in neuroblastoma

2018-01-01

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumour in childhood. Prognosis in the high-risk cases remains poor, highlighting the need for novel therapies. Neuroblastomas are characterised by a fundamental downregulation of mitochondrial respiration and a high glycolytic rate. This is due to genomic aberrations such as MYCN gene amplification and loss of chromosomal regions encoding succinate dehydrogenase...

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Literature Corpus work: 1f266c4d-8b3d-5804-8c41-29165111ff76
DOI: 10.25560/82010

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