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Article

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

3 Jun 2013

Abstract excerpt

The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor clinical outcome in childhood neuroblastoma, yet strategies to modulate the function of MYCN do not exist. Here we show that 10058-F4, a characterized c-MYC/Max inhibitor, also targets the MYCN/Max interaction, leading to cell cycle arrest, apoptosis, and...

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PMID: 23733953
DOI: 10.1073/pnas.1222404110

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