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Article

Metabolic protein kinase signalling in neuroblastoma

4 Jul 2023

Abstract excerpt

BACKGROUND: Neuroblastoma is a paediatric malignancy of incredibly complex aetiology. Oncogenic protein kinase signalling in neuroblastoma has conventionally focussed on transduction through the well-characterised PI3K/Akt and MAPK pathways, in which the latter has been implicated in treatment resistance. The discovery of the receptor tyrosine kinase ALK as a target of genetic alterations in cases of familial and...

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PMID: 37414143
DOI: 10.1016/j.molmet.2023.101771

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