Article

Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent

2025-01-08

Abstract excerpt

The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy. In such patients, persistence of antigenic B. burgdorferi peptidoglycan (PG Bb ) fragments within joint tissues may contribute to immunopathogenesis pre- and post-antibiotic treatment. In live B...

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Literature Corpus work: 1ee7e185-427b-5698-af14-6f4356ff4bfc
DOI: 10.1101/2025.01.08.631998

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