Article
A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?
British journal of haematology - 1 Oct 2014
LeVine Dana N, Birkenheuer Adam J, Brooks Marjory B, Nordone Shila K, Bellinger Dwight A, Jones Sam L, Fischer Thomas H, Oglesbee Stephen E, Frey Kahlina, Brinson Nicole S, Peters Allison P, Marr Henry S, Motsinger-Reif Alison, Gudbrandsdottir Sif, Bussel James B, Key Nigel S
Abstract excerpt
Canine immune thrombocytopenia (ITP) is analogous to human ITP, with similar platelet counts and heterogeneity in bleeding phenotype among affected individuals. With a goal of ultimately investigating this bleeding heterogeneity, a canine model of antibody-mediated ITP was developed. Infusion of healthy dogs with 2F9, a murine IgG2a monoclonal antibody to the canine platelet glycoprotein GPIIb (a common target of...
Topics
- Animals
- Antibodies, Monoclonal
- Blood Platelets
- Cytokines
- Disease Models, Animal
- Dogs
- Hemorrhage
- Phenotype
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic