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Article

Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2012

Qian Feng, Le Breton Guy C, Chen Jia, Deng Jing, Christman John W, Wu Dianqing, Ye Richard D

Abstract excerpt

OBJECTIVE: Recent studies have shown a role for Rac1 in regulating platelet functions, but how Rac1 is activated in platelets remains unclear. Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 (P-Rex1) was originally identified in neutrophils that regulates phagocyte functions. We sought to examine whether P-Rex1 plays a role in platelet activation. METHODS AND RESULTS: Western blotting showed...

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Identifiers

PMID: 22207728
DOI: 10.1161/ATVBAHA.111.243675
PMCID: PMC3288658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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