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Anti-Müllerian hormone serum concentrations of women with germline<i>BRCA1</i>or<i>BRCA2</i>mutations

19 Apr 2016

Abstract excerpt

STUDY QUESTION: Do women with ITALIC! BRCA1 or ITALIC! BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-Müllerian hormone (AMH) concentration? SUMMARY ANSWER: Women with a germline mutation in ITALIC! BRCA1 have reduced ovarian reserve as measured by AMH. WHAT IS KNOWN ALREADY: The DNA repair enzymes encoded by ITALIC! BRCA1 and ITALIC! BRCA2 are implicated in reproductive aging....

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PMID: 27094481
DOI: 10.1093/humrep/dew044

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