Article
Electrophysiological phenotypes of MeCP2 A140V mutant mouse model.
CNS neuroscience & therapeutics - 1 May 2014
Ma Lu-Yao, Wu Chen, Jin Yu, Gao Ming, Li Guo-Hui, Turner Dharshaun, Shen Jian-Xin, Zhang Shi-Jiang, Narayanan Vinodh, Jentarra Garilyn, Wu Jie
Abstract excerpt
AIMS: MeCP2 gene mutations are associated with Rett syndrome and X-linked mental retardation (XLMR), diseases characterized by abnormal brain development and function. Recently, we created a novel MeCP2 A140V mutation mouse model that exhibited abnormalities of cell packing density and dendritic branching consistent with that seen in Rett syndrome patients as well as other MeCP2 mutant mouse models. Therefore, we...
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