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Article

Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations.

Molecular psychiatry - 1 Dec 2012

Farra N, Zhang W-B, Pasceri P, Eubanks J H, Salter M W, Ellis J

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental autism spectrum disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Here, we describe the first characterization and neuronal differentiation of induced pluripotent stem (iPS) cells derived from Mecp2-deficient mice. Fully reprogrammed wild-type (WT) and heterozygous female iPS cells express endogenous pluripotency markers, reactivate the...

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Source

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Identifiers

PMID: 22230884
DOI: 10.1038/mp.2011.180
PMCID: PMC3504383

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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