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Article

Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice.

The Journal of physiology - 15 Mar 2007

Stettner Georg M, Huppke Peter, Brendel Cornelia, Richter Diethelm W, Gärtner Jutta, Dutschmann Mathias

Abstract excerpt

Rett syndrome (RTT) is an inborn neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 gene (MECP2). Besides mental retardation, most patients suffer from potentially life-threatening breathing arrhythmia. To study its pathophysiology, we performed comparative analyses of the breathing phenotype of Mecp2-/y knockout (KO) and C57BL/6J wild-type mice using the perfused working...

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Source

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Identifiers

PMID: 17204503
DOI: 10.1113/jphysiol.2006.119966
PMCID: PMC2151368

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice.PMID 17204503Read ↗

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