Article

Mecp2 deficiency induces dysphagia in a preclinical model of Rett Syndrome

2025-11-19

Abstract excerpt

Rett Syndrome is a rare, x-linked genetic neurological disorder caused by MECP2 gene mutations. This progressive neurodevelopmental disorder hinders patients’ ability to breathe and eat normally. It is unclear how Mecp2- deficiency results in a high percentage of dysphagia and aspiration pneumonia in patients with Rett syndrome. We aim to determine the effects of Mecp2 -deficiency on swallow related neuromuscula...

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Literature Corpus work: b7e78431-123f-568e-8093-37057905674e
DOI: 10.1101/2025.11.19.689305

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