Article

Stepwise C-Terminal Truncation of Cardiac Troponin T Alters Function at Low and Saturating Ca <sup>2+</sup>

2018-04-19

Abstract excerpt

Activation of striated muscle contraction occurs in response to Ca 2+ binding to troponin C (TnC). The resulting reorganization of troponin repositions tropomyosin on actin and permits activation of myosin catalyzed ATP hydrolysis. It now appears that the levels of activity at both low and saturating Ca 2+ are modulated by the C-terminal 14 amino acids of cardiac troponin T (TnT). We made a series of mutants of...

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Literature Corpus work: 1e4b3b81-cb42-58cd-b4db-41b442392f18
DOI: 10.1101/304642

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Stepwise C-Terminal Truncation of Cardiac Troponin T Alters Function at Low and Saturating Ca <sup>2+</sup>DOI 10.1101/304642Read

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